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  • Title: Real-time quantification assay to monitor BCR-ABL1 transcripts in chronic myeloid leukemia.
    Author: Foskett P, Gerrard G, Foroni L.
    Journal: Methods Mol Biol; 2014; 1160():115-24. PubMed ID: 24740226.
    Abstract:
    The BCR-ABL1 fusion gene, the causative lesion of chronic myeloid leukemia (CML) in >95 % of newly presenting patients, offers both a therapeutic and diagnostic target. Reverse-transcription quantitative polymerase chain reaction technology (RT-qPCR), utilizing primer-probe combinations directed to exons flanking the breakpoint junctional region, offers very high levels of both specificity and sensitivity, in a scalable, robust, and cost-effective assay.
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