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  • Title: Unravelling secondary structure changes on individual anionic polysaccharide chains by atomic force microscopy.
    Author: Schefer L, Adamcik J, Mezzenga R.
    Journal: Angew Chem Int Ed Engl; 2014 May 19; 53(21):5376-9. PubMed ID: 24740853.
    Abstract:
    The structural conformations of the anionic carrageenan polysaccharides in the presence of monovalent salt close to physiological conditions are studied by atomic force microscopy. Iota-carrageenan undergoes a coil-helix transition at high ionic strength, whereas lambda-carrageenan remains in the coiled state. Polymer statistical analysis reveals an increase in persistence length from 22.6±0.2 nm in the random coil, to 26.4±0.2 nm in the ordered helical conformation, indicating an increased rigidity of the helical iota-carrageenan chains. The many decades-long debated issue on whether the ordered state can exist as single or double helix, is conclusively resolved by demonstrating the existence of a unimeric helix formed intramolecularly by a single polymer chain.
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