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  • Title: Single-molecule reconstruction of oligonucleotide secondary structure by atomic force microscopy.
    Author: Pyne A, Thompson R, Leung C, Roy D, Hoogenboom BW.
    Journal: Small; 2014 Aug 27; 10(16):3257-61. PubMed ID: 24740866.
    Abstract:
    Based on soft-touch atomic force microscopy, a method is described to reconstruct the secondary structure of single extended biomolecules, without the need for crystallization. The method is tested by accurately reproducing the dimensions of the B-DNA crystal structure. Importantly, intramolecular variations in groove depth of the DNA double helix are resolved, which would be inaccessible for methods that rely on ensemble-averaging.
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