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  • Title: VIP and related peptides induce rapid homologous desensitization in the human lymphoma SUP T1 cell line.
    Author: Robberecht P, De Neef P, Waelbroeck M, Tastenoy M, Christophe J.
    Journal: Peptides; 1989; 10(2):441-6. PubMed ID: 2474155.
    Abstract:
    Incubation of human SUP T1 lymphoblasts with VIP, helodermin and related peptides induced homologous desensitization within 5 min as indicated by: 1) a secondary decrease in cellular cyclic AMP levels, even in the presence of phosphodiesterase inhibitors, 2) a reduced capacity of cells to bind [125I]helodermin, 3) decreased helodermin stimulation of adenylate cyclase activity in membranes, and 4) unaffected NaF- and Gpp[NH]p-stimulated adenylate cyclase activities. The desensitizing ability of all peptides correlated with their efficacy to occupy cell receptors, except for [D-Phe2]VIP, a partial VIP agonist with low intrinsic activity, that did not desensitize.
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