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  • Title: Porphyromonas gingivalis: major periodontopathic pathogen overview.
    Author: Mysak J, Podzimek S, Sommerova P, Lyuya-Mi Y, Bartova J, Janatova T, Prochazkova J, Duskova J.
    Journal: J Immunol Res; 2014; 2014():476068. PubMed ID: 24741603.
    Abstract:
    Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens-Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.
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