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  • Title: Formal synthesis of actin binding macrolide rhizopodin.
    Author: Pulukuri KK, Chakraborty TK.
    Journal: Org Lett; 2014 Apr 18; 16(8):2284-7. PubMed ID: 24742162.
    Abstract:
    Formal synthesis of an actin binding macrolide rhizopodin was achieved in 19 longest linear steps. The key features of the synthesis include a stereoselective Mukaiyama aldol reaction, dual role of a Nagao auxiliary (first, as a chiral auxiliary of choice for installing hydroxy centers and, later, as an acylating agent to form an amide bond with an amino alcohol), late stage oxazole formation, and Stille coupling reactions.
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