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  • Title: VP-16, ifosfamide, and methotrexate combination chemotherapy for aggressive non-Hodgkin's lymphomas after failure of the LNH 84 regimen.
    Author: Herbrecht R, Garcia JJ, Bergerat JP, Dufour P, Duclos B, Oberling F.
    Journal: Cancer Chemother Pharmacol; 1989; 24(5):338-9. PubMed ID: 2474382.
    Abstract:
    A total of 20 patients with intermediate or high-grade non-Hodgkin's lymphomas who failed to LNH 84 regimen were treated with a combination of VP 16, ifosfamide and methotrexate (VIM regimen). Nineteen patients are evaluable for response. Eight patients (42%) achieved complete responses and four (21%) attained partial responses. Most of the complete responders are still in remission with a follow-up of more than 30 months for 5 patients.
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