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  • Title: Photoaffinity labeling of functional states of the nicotinic acetylcholine receptor.
    Author: Oberthür W, Hucho F.
    Journal: J Protein Chem; 1988 Apr; 7(2):141-50. PubMed ID: 2475131.
    Abstract:
    The nicotinic acetylcholine receptor was subjected to photoaffinity labeling in different conformational and functional states. The photolabel used was the ion-channel blocker [3H]-TPMP+. A procedure is described for isolating labeled delta-polypeptide chains from the receptor complex by preparative SDS-polyacrylamide gel electrophoresis. The photolabel was localized in the primary structure of the delta-chain. The site of labeling was found to be identical when photoaffinity labeling was performed in the resting, desensitized, or antagonist state, respectively.
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