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  • Title: Augmentative therapies do not potentiate the antidepressant-like effects of deep brain stimulation in rats.
    Author: Laver B, Diwan M, Nobrega JN, Hamani C.
    Journal: J Affect Disord; 2014 Jun; 161():87-90. PubMed ID: 24751313.
    Abstract:
    BACKGROUND: Clinical trials have shown promising results with the use of subcallosal cingulate gyrus deep brain stimulation (DBS) for treatment-resistant depression. However, strategies to manage patients who do not respond to this therapy have not been explored in detail. In rats, DBS in the ventromedial prefrontal cortex (vmPFC) induces a significant antidepressant-like response in the forced swim test (FST). We have used this test to investigate potential interactions between DBS and clinically used augmentative regimens. METHODS: Rats undergoing the FST were treated with vmPFC DBS along with different augmentative drugs, namely buspirone, risperidone and pindolol. Locomotor activity was tested in an open field. RESULTS: DBS induced a significant reduction in immobility scores as compared to saline treated controls. These antidepressant-like effects, however, were not potentiated by the co-administration of buspirone, risperidone or pindolol. LIMITATIONS: Despite having good predictive validity, animal models are limited from a translational perspective. CONCLUSIONS: Our results indicate that that the antidepressant-like effects of vmPFC DBS in the FST are not enhanced by augmentative therapies.
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