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  • Title: Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.
    Author: Yin JP, Tang CL, Gao LX, Ma WP, Li JY, Li Y, Li J, Nan FJ.
    Journal: Org Biomol Chem; 2014 Jun 07; 12(21):3441-5. PubMed ID: 24752625.
    Abstract:
    A series of structurally related analogues of the natural product paracaseolide A were synthesized and identified as potent PTP1B inhibitors. Among these analogues, compound 10 in particular showed improved PTP1B enzyme inhibitory activity, high selectivity for PTP1B over TC-PTP, and improved cellular effects.
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