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  • Title: [Effect of substance P and its N-terminal fragment on the components of the normal microcirculatory system and under stress].
    Author: Gorizontova MP.
    Journal: Fiziol Zh SSSR Im I M Sechenova; 1989 May; 75(5):709-14. PubMed ID: 2475368.
    Abstract:
    The biomicroscopy experiments showed that the substance P N-terminal fragment (SP1-4) is not as injurious as the SP1-11 for the rat mesentery. The SP1-4/SP1-11 activity ratio is 0.007 to 1 in case of microcirculation disturbances and venular permeability increase, and 0.0007 to 1 in case of the mast cells degranulation increase. Injection of SP1-11 (125 micrograms/kg) prior to the 5-hr immobilization, enhanced the disturbances in microcirculatory system induced by the stress. Injection of SP1-4 (53 micrograms/kg) led to sedative or narcotic effects in 50% of rats correlated with the normalizing terminal blood flow, venular permeability and mast cells secretory activity.
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