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  • Title: [Megakaryocytes and thrombocytopoiesis in idiopathic thrombocytopenic purpura].
    Author: Arendt T, Nizze H, Konrad H.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1989; 116(2):211-7. PubMed ID: 2475399.
    Abstract:
    In idiopathic thrombocytopenic purpura (ITP) patients with histological signs of stronger auto-antibody synthesis (spleen follicle hyperplasia) more frequently revealed megakaryocyte changes due to antibodies and less frequently thrombocyte production compensatory increased than ITP patients with signs of weaker auto-antibody synthesis (spleen follicle normoplasia). The observation suggest that insufficient and frequently lacking compensatory increase of thrombocyte production in ITP is caused by an autoallergic disturbance of megakaryocyte maturation.
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