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  • Title: A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones.
    Author: Ban SR, Zhu XX, Zhang ZP, Li QS.
    Journal: Bioorg Med Chem Lett; 2014 Jun 01; 24(11):2517-20. PubMed ID: 24755429.
    Abstract:
    A benzoylthiourea-pyrrolidine catalyst was developed for the asymmetric Michael addition of ketones to chalcones. The corresponding products were obtained in high yields with high level of diastereoselectivities (up to 99:1 dr) and high level of enantioselectivities (up to 94% ee) under mild conditions.
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