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  • Title: Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg.
    Author: O'Keefe SJ, Wolfes H, Kiessling AA, Cooper GM.
    Journal: Proc Natl Acad Sci U S A; 1989 Sep; 86(18):7038-42. PubMed ID: 2476810.
    Abstract:
    Injection of antisense oligonucleotides was used to investigate the function of c-mos in murine oocytes. Oocytes injected with antisense c-mos oligonucleotides completed the first meiotic division but failed to initiate meiosis II. Instead, loss of c-mos function led to chromosome decondensation, reformation of a nucleus after meiosis I, and cleavage to two cells. Therefore, c-mos is required for meiosis II during murine oocyte maturation.
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