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  • Title: Cytotoxic dimeric quinolone-terpene alkaloids from the root bark of Zanthoxylum rhetsa.
    Author: Ahsan M, Haque MR, Hossain MB, Islam SN, Gray AI, Hasan CM.
    Journal: Phytochemistry; 2014 Jul; 103():8-12. PubMed ID: 24768324.
    Abstract:
    Four quinolone-terpene alkaloids, chelerybulgarine (1), 2'-episimulanoquinoline (3), 2,11-didemethoxyvepridimerine B (4), and rhetsidimerine (5) were isolated from the root bark of Zanthoxylum rhetsa DC. Chelerybulgarine (1) is a C-C linked terpene alkaloid where the C-6 of dihydrochelerythrine is linked to C-11 of the sesquiterpenoid 10β-methoxybulgarene. 2'-Episimulanoquinoline is a dimeric alkaloid containing dihydrochelerythrine and 8-methoxy-N-methylflindersine moieties, whereas 2,11-didemethoxyvepridimerine B and rhetsidimerine are dimeric prenylated quinolone alkaloids. Seven of the isolated compounds exhibited weak cytotoxicity when tested against a panel of six human stomach-cancer cell lines.
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