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  • Title: RNA degrading activity is tightly associated with the multicatalytic proteinase, ingensin.
    Author: Tsukahara T, Tanaka K, Ogawa T, Ishiura S, Funabiki R, Sugita H.
    Journal: FEBS Lett; 1989 Sep 11; 255(1):179-83. PubMed ID: 2477278.
    Abstract:
    The multicatalytic proteinase, ingensin, was purified to homogeneity from chicken liver. rRNA-degrading activity was co-eluted with the purified multicatalytic proteinase from a TSK-3000SW column. This RNA-degrading activity was inactivated by heat treatment and the addition of a low concentration of SDS. Therefore, the RNA-degrading activity co-eluted with the multicatalytic proteinase was not due to contamination by low-molecular-mass RNases. These results strongly suggest that this RNA-degrading activity was tightly associated with the multicatalytic proteinase, ingensin.
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