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  • Title: Fetal hemoglobin heterogeneity in Brazilian newborns and beta-thalassemia homozygotes.
    Author: Zago MA.
    Journal: Haematologica; 1989; 74(4):347-50. PubMed ID: 2477318.
    Abstract:
    The gamma chain composition of HbF in 37 beta-thalassemia homozygotes and 85 unselected newborn babies from Brazil was studied by high performance liquid chromatography (HPLC). The G gamma value of 59.5 +/- 7.5% (mean +/- SD) obtained for the beta-thalassemia homozygotes was significantly lower than the newborn value of 71.2 +/- 4.2%. The A gamma T gene frequency was 0.159 for the newborns and 0.454 for the thalassemia homozygotes. The A gamma T gene occurred both in chromosomes bearing the beta(0)-thalassemia gene and those with the beta(+)-thalassemia gene.
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