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Title: Genotoxic effect of benzene hexachloride in cultured human lymphocytes. Author: Rupa DS, Reddy PP, Reddi OS. Journal: Hum Genet; 1989 Oct; 83(3):271-3. PubMed ID: 2477324. Abstract: Chromosomal aberrations, sister chromatid exchanges, mitotic index and cell kinetics were observed in human peripheral lymphocytes after treatment with four different concentrations (0.0125, 0.025, 0.05 and 0.1 microgram/ml) of benzene hexachloride (BHC), an organochlorine pesticide. Cells were treated with BHC for 24, 48 and 72 h. There was a dose-dependent increase in the frequency of chromosomal aberrations and sister chromatid exchanges. A significant decrease in mitotic index was observed at all concentrations and times of exposure. BHC did not show a significant effect on cell kinetics.[Abstract] [Full Text] [Related] [New Search]