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  • Title: [Histochemical studies of transepidermal elimination of nevus cells in nevus cell nevi of the corium].
    Author: Wollina U, Schaarschmidt H, Henkel U, Knopf B, Hipler C.
    Journal: Z Hautkr; 1989 Aug 15; 64(8):694-6, 699. PubMed ID: 2477958.
    Abstract:
    Dermal nevocytic nevi (NN) were histochemically studied with the help of FITC-conjugated lectins as well as antisera against keratin and plasminogen activators of the urokinase type. 3 out of 18 NN showed interpenetrating nevus cells in atrophic parts of the epidermis. These cells revealed strong lectin reactivity both with Con A (cytoplasmatic binding) and WGA/RCA II (membraneous binding). In addition we found membraneous reaction with anti-urokinase, whereas there was no anti-keratin staining. Our findings suggest active transepidermal elimination of nevus cells in dermal nevocytic nevi.
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