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  • Title: Reporter-triggered isothermal exponential amplification strategy in ultrasensitive homogeneous label-free electrochemical nucleic acid biosensing.
    Author: Nie J, Zhang DW, Zhang FT, Yuan F, Zhou YL, Zhang XX.
    Journal: Chem Commun (Camb); 2014 Jun 14; 50(47):6211-3. PubMed ID: 24781659.
    Abstract:
    A simple and novel reporter-triggered isothermal exponential amplification reaction (R-EXPAR) integrated with a miniaturized electrochemical device was developed, which achieved excellent improvement (five orders of magnitude) of sensitivity toward reporter, G-quadruplex. This R-EXPAR strategy has been successfully implemented to construct a homogeneous label-free electrochemical sensor for ultrasensitive DNA detection.
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