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  • Title: Selective inhibition by vasocortin of histamine release induced by dextran and concanavalin-A from rat peritoneal cells.
    Author: Carnuccio R, Di Rosa M, Ialenti A, Iuvone T, Sautebin L.
    Journal: Br J Pharmacol; 1989 Sep; 98(1):32-4. PubMed ID: 2478246.
    Abstract:
    Vasocortin, a glucocorticoid-induced anti-inflammatory protein, has been purified from the peritoneal lavage fluid of dexamethasone-treated rats. Vasocortin inhibited the release of histamine from rat peritoneal cells stimulated by dextran or concanavalin A but did not alter the release induced by calcium ionophore A23187 or compound 48/80. This selective effect exhibited by vasocortin mimics the glucocorticoid inhibition of histamine release from rat mast cells.
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