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  • Title: Generation of geometrically ordered lipid-based liquid-crystalline nanoparticles using biologically relevant enzymatic processing.
    Author: Fong WK, Salentinig S, Prestidge CA, Mezzenga R, Hawley A, Boyd BJ.
    Journal: Langmuir; 2014 May 20; 30(19):5373-7. PubMed ID: 24783947.
    Abstract:
    High-symmetry lipid nanoparticles with internal bicontinuous cubic phase structure (cubosomes) are prepared from a simple emulsion containing a mixture of a nondigestible lipid (phytantriol) and a digestible short-chained triglyceride using enzymatic lipolysis of the incorporated short-chained triglyceride. The lipolytic products partition away from the nondigestible lipid, resulting in crystallization of the cubic-phase internal structure. Time-resolved small-angle X-ray scattering revealed the kinetics of the disorder-to-order transition, with cryo-transmission electron microscopy showing an absence of liposomes. The new approach offers a new "sideways" method for the generation of lipid-based nanostructured materials that avoids the problems of top-down and bottom-up approaches.
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