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Title: Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Author: Iida T, Kobayashi E, Yoshida M, Sano H. Journal: J Antibiot (Tokyo); 1989 Oct; 42(10):1475-81. PubMed ID: 2478515. Abstract: The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.[Abstract] [Full Text] [Related] [New Search]