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  • Title: Purification and properties of the voltage-dependent anion channel of the outer mitochondrial membrane.
    Author: Palmieri F, De Pinto V.
    Journal: J Bioenerg Biomembr; 1989 Aug; 21(4):417-25. PubMed ID: 2478528.
    Abstract:
    The methods for the purification of functionally active mitochondrial porin or voltage-dependent anion channel of the outer mitochondrial membrane are critically evaluated. Two rapid and efficient methods are now available. Both make use of a hydroxyapatite/celite column as a single chromatographic step. However, in one method with long polar head-group detergents, porin passes through the column, whereas in the other method, with shorter polar head-group detergents, porin is first bound to the column and then eluted by the addition of salts. On the basis of these results, a model for the arrangement of porin in the detergent-protein micelles is proposed.
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