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  • Title: Basophil degranulation test in house dust mite allergy: diagnostic value.
    Author: Feliu X, de la Cuesta CG, Castillo JG, Sanz ML, Oehling A.
    Journal: Allergol Immunopathol (Madr); 1989; 17(4):193-6. PubMed ID: 2479246.
    Abstract:
    After reviewing the experience of various authors we applied the Basophil Degranulation Test (BDT) in the study of sensitization to Dermatophagoides pteronyssinus, so as to evaluate its diagnostic use. Fifty-five patients with asthma and/or rhinitis and a positive skin test to the mentioned antigen, as well as 20 control subjects were studied. The results demonstrated a sensitivity of 65.5% and a specificity of 80% with an efficiency index of 69.5%. We did not find any significant correlation with the histamine release test (r = 0.236). The data obtained and the proper limitations of the technique led us to consider the BDT to have a limited application in routine allergy diagnosis.
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