These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis and biological evaluation of (+)-neopeltolide analogues: importance of the oxazole-containing side chain.
    Author: Fuwa H, Noguchi T, Kawakami M, Sasaki M.
    Journal: Bioorg Med Chem Lett; 2014 Jun 01; 24(11):2415-9. PubMed ID: 24792465.
    Abstract:
    We describe the synthesis and biological evaluation of (+)-neopeltolide analogues with structural modifications in the oxazole-containing side chain. Evaluation of the antiproliferative activity of newly synthesized analogues against A549 human lung adenocarcinoma cells and PANC-1 human pancreatic carcinoma cells have shown that the C19-C20 and C26-C27 double bonds within the oxazole-containing side chain and the terminal methyl carbamate group are essential for potent activity.
    [Abstract] [Full Text] [Related] [New Search]