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  • Title: Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system.
    Author: Zhou L, Zhou L, Wei S, Ge X, Zhou J, Jiang H, Li F, Shen J.
    Journal: J Photochem Photobiol B; 2014 Jun 05; 135():7-16. PubMed ID: 24792568.
    Abstract:
    Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.
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