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  • Title: Nucleolar organizer regions in transitional cell tumors of the bladder.
    Author: Cairns P, Suarez V, Newman J, Crocker J.
    Journal: Arch Pathol Lab Med; 1989 Nov; 113(11):1250-2. PubMed ID: 2479357.
    Abstract:
    The traditional silver staining technique that identifies nucleolar organizer region-associated proteins has recently been adapted and applied to paraffin sections, and used to examine changes in nucleolar organizer region numbers in a variety of benign and malignant conditions. We describe herein the enumeration of nucleolar organizer regions in a variety of benign and malignant conditions of the transitional epithelium of the urinary bladder. While there is a statistical separation between normal and neoplastic groups, there is a degree of overlap between normal, inflammatory, dysplastic, and neoplastic urothelium.
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