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  • Title: Detection of retrovirus particles and reverse transcriptase activity in mid-term cultured peripheral blood and lymph node cells from a French woman with Sezary syndrome.
    Author: Saal F, Gessain A, Lasneret J, Foldès C, Dronne P, Wallach D, Cottenot F, Sigaux F, Flandrin G, Périès J.
    Journal: Nouv Rev Fr Hematol (1978); 1989; 31(5):333-7. PubMed ID: 2479905.
    Abstract:
    Retrovirus particles, with an ultrastructure of type C-virus similar to HTLV-I were observed in several mid-term cultures of leukemic cells derived from a woman with a well characterised Sezary syndrome who had always resided in France. Reverse transcriptase activity was detected in supernatant fluids from day 6 to day 40 of culture. However, negative anti HTLV-I serology and the absence of specific molecular hybridization between leukemic cell DNA and two HTLV-I derived probes, argue against a HTLV-I virus.
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