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  • Title: [Farmacological effect of retabolil on aldosterone level and arterial pressure in rats under the action of vibrations].
    Author: Obut TA, Ovsiukova MV, Egorova SA, Érdynieva TA, Dement'eva TIu, Obut ET.
    Journal: Eksp Klin Farmakol; 2014; 77(3):9-12. PubMed ID: 24800518.
    Abstract:
    The experiments were performed on male rats, which were subjected to single and multiply repeated vibrations (low-frequency, horizontal, high-amplitude) analogous to the action of motor transport vibrations. It is established that the administration of retabolil produces a hypotensive effect and blocks the vibration-induced increase in the level of hypertensive hormone aldosterone. Under conditions of the multiply repeated action of vibrations, both effects were realized via micro-opioid receptors. In the case of a single action, these receptors were only involved in a hypotensive effect but not mediated in aldosterone suppression. Both these effects were absent in the control group of animals (not subjected to vibrations). Therefore, retabolil can be used as a hypotensive and aldosterone-blocking drug for vibration-induced hypertension in animals and, probably, in humans.
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