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  • Title: Infantile generalized pustular psoriasis: successful disease control with intermittent etretinate.
    Author: Namba C, Murakami M, Hanakawa Y, Tohyama M, Shirakata Y, Tauchi H, Sayama K.
    Journal: J Dermatol; 2014 May; 41(5):403-6. PubMed ID: 24801915.
    Abstract:
    Infantile generalized pustular psoriasis is a rare form of psoriasis and the best treatment is controversial. We experienced a 2-year-old female with erythema on her neck and axilla starting at 3 months of age. She presented with recurrent annular and geographic scaly erythema with a few pustules on the neck, precordium and axilla, but no fever. The histopathology revealed subcorneal neutrophilic infiltration and microabscesses without Kogoj's spongiform pustules. The initial diagnosis was subcorneal pustular dermatosis. However, she developed widespread geographic erythema and numerous pustules over her entire body with a fever when she got a cold. A second skin biopsy revealed monolocular pustules and Kogoj's spongiform pustules in the subcorneal layer. Etretinate was administrated after a diagnosis of pustular psoriasis was made and her condition improved gradually. The choice of treatment depends on patient age, general condition and the disease severity.
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