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  • Title: Improved survival following HLA-incompatible bone marrow transplantation. Munich Cooperative Group of Bone Marrow Transplantation.
    Author: Kolb HJ, Bender-Götze C, Holler E, Mittermüller J, Grosse-Wilde H, Wank R, Eckstein R, Scholz S, Haas RJ, Mempel W.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1989; 116(3-4):421-5. PubMed ID: 2480284.
    Abstract:
    In most centers allogeneic bone marrow transplantation is restricted to patients with HLA-identical siblings as donors. We have transplanted 16 patients with marrow of donors other than HLA-identical siblings. Seven patients were grafted in the years 1978 until 1984. Six died of transplant complications and one of recurrent leukemia. More recently 9 patients were transplanted following an improved immunosuppressive conditioning treatment derived from experimental studies in dogs. Four are alive and in continuous remission between more than 2 months and 2 years. 5 patients died, 3 from fungal infections, one from recurrent leukaemia and one early from endothelial leakage syndrome. Our results indicate that intensified immunosuppressive conditioning may improve the results of marrow transplantation from HLA-haploidentical donors.
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