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  • Title: Cloning by functional expression of a member of the glutamate receptor family.
    Author: Hollmann M, O'Shea-Greenfield A, Rogers SW, Heinemann S.
    Journal: Nature; 1989 Dec 07; 342(6250):643-8. PubMed ID: 2480522.
    Abstract:
    We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.
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