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  • Title: Radiation-induced dedifferentiated chondrosarcoma with orbital invasion.
    Author: Davies BW, Prescott CR, Said SA, Campana J, Attié-Castro FA, Velasco E Cruz AA, Durairaj VD.
    Journal: Ophthalmic Plast Reconstr Surg; 2014; 30(3):205-8. PubMed ID: 24807535.
    Abstract:
    PURPOSE: To report 2 interventional cases of dedifferentiated chondrosarcoma with orbital involvement after radiotherapy performed in childhood and to review the literature on chondrosarcoma in the orbit following radiation treatment. METHODS: Retrospective analysis of medical records of 2 patients with chondrosarcoma of the orbits with review of the literature. RESULTS: The first patient developed chondrosarcoma of the orbital and maxillary sinus 36 years after external beam radiation therapy to the OS to treat retinoblastoma. The second patient developed a large orbital chondrosarcoma 35 years after external beam radiation therapy in the treatment of craniofacial fibrous dysplasia. CONCLUSIONS: These cases highlight the risk of secondary chondrosarcoma in patients following radiotherapy and the importance of lifetime monitoring.
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