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  • Title: Endoplasmic storage disease of liver: characterization of intracytoplasmic hyaline inclusions.
    Author: Ng IO, Ng M, Lai EC, Wu PC.
    Journal: Histopathology; 1989 Nov; 15(5):473-81. PubMed ID: 2480934.
    Abstract:
    Two cases of endoplasmic storage disease of liver are described. The liver tissue in each case showed numerous intracytoplasmic hyaline inclusions of varying sizes with formation of ground-glass hepatocytes. These inclusions were pale eosinophilic in hematoxylin & eosin stained sections, and were periodic acid-Schiff and HBsAg negative. Immunoperoxidase studies revealed strong positivity for fibrinogen and complement components C3 and C4 in case 1 and exclusive positivity for fibrinogen in case 2. On electron microscopy, the inclusions appeared as granular or fibrillar material within dilated cisternae of rough endoplasmic reticulum.
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