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  • Title: Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis.
    Author: Takahashi T, Asano Y, Sunaga R, Ichimura Y, Taniguchi T, Yamamoto M, Tamaki Z, Takekoshi T, Mitsui H, Sugaya M, Ohse T, Sato S.
    Journal: J Dermatol; 2014 Jun; 41(6):533-5. PubMed ID: 24814462.
    Abstract:
    Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.
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