These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: [In vitro aging of erythrocytes].
    Author: Klinger M.
    Journal: Folia Haematol Int Mag Klin Morphol Blutforsch; 1989; 116(5):693-700. PubMed ID: 2481614.
    Abstract:
    Various in vitro-aging procedures are introduced as an alternative to the difficult isolation of physiologically aged erythrocytes standing immediately before elimination. N-acetylneuraminic acid, ATP- and glutathione contents of these model cells are estimated and the kind and degree of membrane damage were characterized by the rates of phagocytosis and exovesiculation. Conclusions concerning molecular biological mechanisms of age-related processes were drawn by correlating biochemical data with the degree of membrane lesion. Alterations of spectrin (cross-linking, aggregation, rearrangement) seem to play the main role in all in vitro-ageing processes described here.
    [Abstract] [Full Text] [Related] [New Search]