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  • Title: Light-dependent Na(+)-Ca2+ exchange in retinal rod discs.
    Author: Volotovski ID, Khovratovich VI, Orlov SN.
    Journal: Gen Physiol Biophys; 1989 Dec; 8(6):589-601. PubMed ID: 2482219.
    Abstract:
    Experiments are described demonstrating that Na(+)-Ca2+ exchange of retinal rod disc membrane is highly sensitive to light. The Na(+)-Ca2+ exchanger was shown to possess two types of binding sites with different affinities for calcium. The low affinity binding sites (KCaD = 5.8 mumol/l) are light-insensitive. After bleaching, KD of the high affinity Ca2(+)-binding sites an Ki for Na+ changed from 0.2 to 0.3 mumol/l and from 3.2 to 0.7 nmol/l, respectively. Light inhibits the steady-state Ca2+ uptake by a factor of 1.5. Photocontrol of the Na(+)-Ca2+ exchanger affinity is observed at the physiological level of rhodopsin bleaching.
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