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  • Title: A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.
    Author: Nadeau JH, Berger FG, Cox DR, Crosby JL, Davisson MT, Ferrara D, Fuchs E, Hart C, Hunihan L, Lalley PA.
    Journal: Genomics; 1989 Oct; 5(3):454-62. PubMed ID: 2482246.
    Abstract:
    Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.
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