These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Serum insulin-like growth factor-binding protein-3 level correlated with glycemic control and lipid profiles in children and adolescents with type 1 diabetes.
    Author: Kim MS, Lee DY.
    Journal: J Pediatr Endocrinol Metab; 2014 Sep; 27(9-10):857-61. PubMed ID: 24825082.
    Abstract:
    Increasing evidence suggests a role of the IGF axis in the maintenance of normal glucose and lipid metabolism. The local IGF-IGFBP environment changes significantly in response to the diabetes milieu. We aimed at determining serum IGF-1 and IGFBP-3 levels in children with type 1 diabetes mellitus (T1DM) and their relationship with clinical variables. Seventy-eight patients with T1DM and 47 healthy control subjects were included in this study. Significant reduction for concentration of serum IGF-1 was observed in patients with T1DM compared to healthy controls. However, serum IGFBP-3 levels were similar in patients with T1DM compared to controls. Both serum IGF-1 and IGFBP-3 levels were significantly correlated with age, BMI, and serum c-peptide levels. In addition, serum IGFBP-3 levels showed significant positive correlation with HbA1c, total cholesterol, and LDL-cholesterol in the uncontrolled diabetic patients. These findings suggest that IGFBP-3 may be involved in the glucose control and lipid metabolism in those with uncontrolled T1DM. Further studies are needed to document their roles on glucose and lipid metabolism in T1DM.
    [Abstract] [Full Text] [Related] [New Search]