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  • Title: Americanin B protects cultured human keratinocytes against oxidative stress by exerting antioxidant effects.
    Author: Zheng J, Piao MJ, Kim KC, Yao CW, Cha JW, Kim SM, Hyun CL, Chae S, Ahn YS, Hyun JW.
    Journal: In Vitro Cell Dev Biol Anim; 2014 Sep; 50(8):766-77. PubMed ID: 24825376.
    Abstract:
    We evaluated the cytoprotective effects of americanin B, a lignan compound, against hydrogen peroxide (H2O2)-induced cell damage. Americanin B decreased the level of DPPH radicals, superoxide anions, hydroxyl radicals, and intracellular reactive oxygen species. Americanin B also attenuated DNA damage induced by H2O2 treatment, as shown by the inhibition of formation of comet tails, indicative of DNA strand breakage, and prevented the oxidation of protein and peroxidation of lipid, as determined by protein carbonyls and 8-isoprostane. Furthermore, americanin B protected against H2O2-induced apoptotic cell death, as determined by a reduction in the numbers of apoptotic bodies stained with Hoechst 33342. These findings suggest that americanin B protects cells against oxidative damage by exerting antioxidant effects and inhibiting apoptosis.
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