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  • Title: Effect of uridine dethiolation in the anticodon triplet of tRNA(Glu) on its association with tRNA(Phe).
    Author: Houssier C, Degée P, Nicoghosian K, Grosjean H.
    Journal: J Biomol Struct Dyn; 1988 Jun; 5(6):1259-66. PubMed ID: 2482764.
    Abstract:
    The effect of U(34) dethiolation on the anticodon-anticodon association between E. coli tRNA(Glu) and yeast tRNA(Phe) has been studied by the temperature jump relaxation technique. An important destabilization upon replacement of the thioketo group of s2U(34) by a keto group, was revealed by a lowering of melting temperature of about 20 degrees C. The measured kinetic parameters indicated that this destabilization effect was originated in an increase of dissociation and a decrease of association rate constants by a factor of 4 to 5. Modifications in both stacking interactions and flexibility in the anticodon loop would be responsible for this effect.
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