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  • Title: Genome-wide association study identifies genomic regions of association for cruciate ligament rupture in Newfoundland dogs.
    Author: Baird AE, Carter SD, Innes JF, Ollier W, Short A.
    Journal: Anim Genet; 2014 Aug; 45(4):542-9. PubMed ID: 24835129.
    Abstract:
    Cranial cruciate ligament rupture (CCLR) is the most common cause of pelvic limb lameness in dogs. To investigate the genetic basis of canine CCLR, we conducted a genome-wide association study using a canine SNP array in Newfoundland pedigree dogs with and without CCLR (n = 96). We identified three main chromosomal regions of CCLR association (on chromosomes 1, 3 and 33). Each of these regions was confirmed by Sequenom genotyping in a further cohort of Newfoundlands (n = 271). The results, particularly SNPs identified in the SORCS2 and SEMA5B genes, suggest that there may be neurological pathways involved in susceptibility to canine CCLR.
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