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  • Title: Effects of tachykinins on mucus secretion in human bronchi in vitro.
    Author: Rogers DF, Aursudkij B, Barnes PJ.
    Journal: Eur J Pharmacol; 1989 Dec 19; 174(2-3):283-6. PubMed ID: 2483550.
    Abstract:
    We examined the effects of mammalian tachykinins on human bronchial secretion in vitro using fucose as an endogenous marker for mucus. Substance P (SP, 10(-9)-10(-5) M) increased secretion in a dose-related manner and was more potent than neurokinin A or neurokinin B. The enkephalinase (endopeptidase 24.11) inhibitor phosphoramidon (10(-5) M) potentiated the effect of SP (10(-7) M). SP is a potent stimulant of secretion in human bronchi and enkephalinase may modulate its effects.
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