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  • Title: Monoclonal IgM gammopathy with anti-myelin associated glycoprotein (MAG) activity and polyneuropathy. A study of three cases.
    Author: Sindic CJ, Boucquey D, Bisteau M, Laloux P, Brucher JM, Laterre C.
    Journal: Acta Neurol Belg; 1989; 89(5):331-45. PubMed ID: 2483599.
    Abstract:
    The authors describe three patients with a chronic sensory-motor polyneuropathy associated with a monoclonal IgM gammopathy. In each case, the M-component was shown to display an antibody activity against the Myelin-Associated Glycoprotein (MAG) in a western blot technique. Sera from the three patients stained specifically the myelin sheaths of normal human peripheral nerves after incubation with rabbit anti-IgM. Motor conduction velocities were very low in each case. Morphological studies of the sural nerve from one patient revealed a moderate loss of myelinated fibres, some onion-bulbs but also a microangiopathy and signs of axonal degeneration.
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