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  • Title: Granulocyte colony-stimulating factor: preclinical and clinical studies.
    Author: Gabrilove JL, Jakubowski A.
    Journal: Hematol Oncol Clin North Am; 1989 Sep; 3(3):427-40. PubMed ID: 2483722.
    Abstract:
    The production of neutrophil granulocytes is a complex and dynamic process during which a small number of self-renewing stem cells give rise to lineage-specific progenitors. One hematopoietic glycoprotein that appears to specifically control the survival, cycle activation, proliferation and terminal maturation of this myeloid lineage is granulocyte colony-stimulating factor (G-CSF). Some topics discussed are its molecular characterization, biochemical purification, sources, and effects of administration.
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