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  • Title: [Clinical significance of fibronectin and protease inhibitors in chronic obstructive pulmonary diseases].
    Author: Dong BR.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1989 Dec; 12(6):343-6, 381. PubMed ID: 2483984.
    Abstract:
    Plasma fibronectin (Fn) and protease inhibitors (alpha 2-macroglobulin, alpha 2-MG, antithrombin, AT-III activity and content) were measured in 74 COPD patients and 53 normal controls. It was showed: (1) Fn, alpha 2-MG. AT-III activity were considerably decreased in COPD, when compare with that of controls; (2) there is a negative correlation between the value of PaCO2, r = -0.719, P less than 0.01. It indicated that the Fn, AT-III activity and alpha 2-MG are closely correlated with the extent and degree of respiratory decompensation. Dynamic changes of these parameters are of some prognostic significance in COPD.
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