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  • Title: "Turn-on" fluorescent dipodal chemosensor for nano-molar detection of Zn(2+): application in living cells imaging.
    Author: Fegade U, Sharma H, Bondhopadhyay B, Basu A, Attarde S, Singh N, Kuwar A.
    Journal: Talanta; 2014 Jul; 125():418-24. PubMed ID: 24840466.
    Abstract:
    A malonohydrazide derivative bearing an imine and phenolic group was synthesized and had a high affinity and selectivity towards Zn(2+). The recognition properties of receptor 1 were evaluated using absorbance and fluorescence spectroscopy. The 1:1 stoichiometry of 1.Zn(2+) was confirmed from job's plot, mass spectra and density functional theory (DFT). The detection of Zn(2+) in intracellular environment of HeLa cell through confocal microscopy was successfully applied for live cell imaging.
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