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  • Title: A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors.
    Author: Kong XD, Ma Q, Zhou J, Zeng BB, Xu JH.
    Journal: Angew Chem Int Ed Engl; 2014 Jun 23; 53(26):6641-4. PubMed ID: 24841567.
    Abstract:
    Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates.
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