These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sequential changes in plasma methylmalonic acid and vitamin B12 in sheep eating cobalt-deficient grass.
    Author: Rice DA, McLoughlin M, Blanchflower WJ, McMurray CH, Goodall EA.
    Journal: Biol Trace Elem Res; 1989 Nov; 22(2):153-64. PubMed ID: 2484236.
    Abstract:
    Methylmalonic acid (MMA) concentrations are elevated in plasma as a result of vitamin B12 deficiency. This study reports the sequential changes in plasma MMA in lambs maintained on a cobalt-deficient pasture compared with supplemented controls. The results indicate that MMA is elevated in the early stages of deficiency, preceding the onset of loss of production and clinical signs of disease. It remains elevated as long as the lambs are unsupplemented with cobalt (Co). The most striking clinical sign was a loss of body condition as opposed to weight. The defect in the methylmalonyl CoA mutase is obviously an early defect in cobalt deficiency.
    [Abstract] [Full Text] [Related] [New Search]